Principal Research Scientist I, Small Molecule ARD

Company: Allergan
Location: Lincoln
Posted on: February 17, 2025

Job Description:

Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on , , , , and .Job DescriptionAbbVie Analytical Research & Development (Analytical R&D) is a global analytical scientific organization responsible for all CMC analytical activities related to the development of AbbVie's pharmaceutical products. Our scope includes AbbVie's diverse pipeline of innovative small molecule medicines and spans from the selection of Discovery candidate molecules to Late Stage Clinical. We are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVie's pipeline of innovative medicines. Careers in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development strategies. We are looking for diverse candidates with strong scientific experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates.Position Description:For the Senior Scientist II position, we are seeking a highly motivated candidate who can conceive, implement and execute novel scientific research and development. Generate new scientific proposals and lead these efforts. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research and development programs.He/she should possess an understanding of core discipline and support early phase development of New Chemical Entities (NCEs) drug substance and drug product for both preclinical and clinical programs. Collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Discovery, Pre-Clinical Safety (PCS), Process Chemistry, Process Engineering, Drug Product Development (DPD), and Quality Assurance (QA) and CMC-Regulatory.Responsibilities:

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to further the understanding of emerging cGMP manufacturing processes.
• Responsible for leading the analytical aspects of a project while working with other functional areas to advance projects through the development pipeline from preclinical to clinical candidates.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related to small-molecule active pharmaceutical ingredients, intermediates, starting materials, impurities along with pre-clinical to clinical formulations.
• Assess stability liabilities of early development assets, including identification of degradation pathways and structural elucidation of degradation products.
• Development of stability indicating methods using a variety of analytical separation (HPLC/UHPLC) and detection modes (UV, MS, CAD) for active pharmaceutical ingredients.
• Highly autonomous and productive in performing laboratory research or method development, requiring only minimal direction from or interaction with supervisor.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• May initiate new areas of investigation that are scientifically meaningful, robust, and can be incorporated directly into a research or development program.
• Process, interpret, and visualize diverse data sets to facilitate project team decisions.
• Communicate and collaborate with cross-functional groups and departments.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Translate data packages to target audiences/functions throughout project lifetime.
• Raises the bar and is never satisfied with the status quo.
• Understand and adhere to corporate standards regarding code of conduct and safety along with GLP and GxP compliance, where applicable.Qualifications:
  • Bachelors, Masters, or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS), 12 (MS), or 6 (Ph.D.) years related industry experience.
  • Strong technical background in analytical chemistry, excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
  • Hands-on experience with HPLC analysis and method development along with expertise and fundamental understanding of spectroscopic techniques.
  • Self-motivated, hard-working, detail-oriented individual able to work in a fast-paced team environment.
  • Experience in the use of computerized data handling systems.
  • High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
  • Practical knowledge of organic structure, functional groups, chemistry, and modern spectroscopic techniques as applied to small-molecule analytical analysis.
  • Builds strong relationships with peers and cross-functionally with partners outside of team to enable higher performance.
  • Learns fast, grasps the "essence" and can change course quickly where indicated.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others, nurtures innovation and manages innovation to reality.Additional Information:Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
    • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
    • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
    • This job is eligible to participate in our short-term incentive programs.
    • This job is eligible to participate in our long-term incentive programs.Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.US & Puerto Rico only - to learn more, visit US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
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Keywords: Allergan, Lincoln , Principal Research Scientist I, Small Molecule ARD, Other , Lincoln, Nebraska